2-(4-Aminophenyl)-1H-benzimidazol-5-amine (APBIA) CAS 7621-86-5

Synonyms: 2-(4-Aminophenyl)-5-aminobenzimidazole; 5-Amino-2-(4-aminophenyl)benzimidazole; 1H-Benzimidazol-5-amine, 2-(4-aminophenyl)-; 1H-Benzimidazol-6-amine, 2-(4-aminophenyl)-; 2-(4-Aminophenyl)-1H-benzo[d]imidazol-5-amine; 5(6)-Amino-2-(p-aminophenyl)benzimidazole; 

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Product Details

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2-(4-Aminophenyl)-1H-benzimidazol-5-amine (APBIA), CAS 7621-86-5, is a benzimidazole derivative and diamine monomer known for its solubility in organic solvents, low toxicity, and potential biological activities, making it suitable as an intermediate in polymer synthesis and pharmaceutical development.

Basic Information of APBIA

Product Name	2-(4-Aminophenyl)-1H-benzimidazol-5-amine
Abbreviation	APBIA
CAS Number	7621-86-5
Molecular Formula	C13H12N4
Molecular Weight	224.26 g/mol
Appearance	Pale Beige to Pale Brown Solid
Purity	≥99%
Package	1kg/bottle, 20kg/drum, or customized
Molecular formula

Key Properties

High thermal stability, thanks to the benzimidazole core structure
Dual amino functionality for polymerization and crosslinking capability
Good chemical resistance and stability in harsh environments
Potential for incorporation in functional membranes (e.g. proton exchange)
Moderate polarity, enabling interactions in composite / interface systems

Key Applications of APBIA

Battery Materials: Used as a component in aerogel lithium battery separators and for preparing sulfonated polyimides containing benzimidazole (SPIBIs) combined with polyhedral oligomeric silsesquioxane glycidyl ethers (G-POSS) to create organic-inorganic hybrid proton exchange membranes (PEMs).

High-Performance Polymers: Serves as a monomer to optimize polyimide properties, enhancing performance in materials requiring thermal stability and mechanical strength.

Pharmaceuticals: Employed in drug development for anti-cancer agents (inhibiting kinases in cancer signaling pathways), antiviral compounds (e.g., against hepatitis C virus), and anti-inflammatory drugs (inhibiting cyclooxygenase enzymes); valued for its bioavailability and low toxicity.

Organic Synthesis: Acts as a versatile intermediate in pharmaceutical research and organic synthesis, facilitating the creation of novel compounds.

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