Explore Top-Quality Chlorotrimethylsilane (CAS 75-77-4) with Aure Chemical
Aure Chemical is a premier global supplier of high-quality Chlorotrimethylsilane (Me₃SiCl), commonly known as Trimethylsilyl Chloride (TMCS). Identified by its CAS number 75-77-4, this organosilicon compound is a colorless, fuming liquid with a strong, irritating odor. Chlorotrimethylsilane is an exceptionally versatile and powerful silylating reagent in organic synthesis. It plays an indispensable role in protecting a wide array of functional groups (like alcohols, amines, and carboxylic acids) as their trimethylsilyl ethers or derivatives, making them inert to various reactions. Beyond protection, it's widely used for introducing the trimethylsilyl group into molecules, facilitating complex transformations in the manufacturing of pharmaceuticals, agrochemicals, and silicone-based intermediates. Due to its reactivity with moisture and corrosive nature, handling and transportation of Chlorotrimethylsilane require meticulous care and adherence to strict safety protocols. Aure Chemical's unwavering commitment to excellence ensures that our Chlorotrimethylsilane meets the stringent purity and performance requirements for your most demanding industrial and laboratory applications, guaranteeing consistency, safety, and reliability.
Product Overview & Key Properties
Chlorotrimethylsilane (CAS No. 75-77-4) is meticulously produced and rigorously tested to meet stringent quality standards. We ensure exceptional purity and consistent performance, essential for your critical applications:
| CAS No.: | 75-77-4 |
| EC No.: | 200-900-5 |
| Linear Formula: | (CH₃)₃SiCl |
| Molecular Weight: | 108.64 |
| Appearance: | Clear, colorless, fuming liquid. |
| Odor: | Pungent odor. |
| Melting Point: | −40 °C(lit.) |
| Boiling point: | 57 °C(lit.) |
| Density: | 0.857 g/mL at 25 °C |
| Reactivity: | Reacts vigorously with water (hydrolyzes to hexamethyldisiloxane and hydrochloric acid), alcohols, amines, and other protic solvents. |
| Flammability: | Flammable liquid and vapor. |
| Corrosivity: | Corrosive to metals in the presence of moisture and to organic tissues. |
| RIDADR: | UN 1298 3/PG 2 |
| Chemical Structure: |  |
Our commitment to delivering high-purity Chlorotrimethylsilane ensures a reliable and efficient component for your critical processes, offering consistent quality for diverse industrial needs, while prioritizing uncompromising safety in handling and logistics.
Primary Applications of Chlorotrimethylsilane
Chlorotrimethylsilane's unique reactivity and ability to introduce the trimethylsilyl group make it an indispensable reagent with extensive applications across various chemical synthesis pathways:
Protecting Group:
One of its most widespread uses is as a protecting group for various functional groups in organic synthesis. It efficiently converts alcohols, phenols, carboxylic acids, and amines into their trimethylsilyl derivatives, which are often more stable, volatile, or unreactive to specific reagents, allowing for selective transformations elsewhere in the molecule.
Silylating Agent:
It acts as a versatile silylating agent, introducing the trimethylsilyl group (Me₃Si– ) into organic molecules. This can modify physical properties, enhance solubility, or facilitate subsequent reactions.
Pharmaceutical Manufacturing:
Chlorotrimethylsilane is a crucial intermediate and reagent in the synthesis of numerous active pharmaceutical ingredients (APIs) and their precursors. Its role in protecting sensitive groups and enabling specific reactions is vital in complex drug synthesis routes.
Agrochemical Production:
It is widely employed in the synthesis of various agrochemicals, including pesticides, herbicides, and plant growth regulators, where silylation plays a role in modifying reactivity or stability.
Analytical Chemistry:
Used in analytical chemistry for derivatization, particularly to increase the volatility of polar compounds (like amino acids, sugars) for gas chromatography (GC) analysis, enabling their detection and quantification.
Production of Silicone Intermediates:
Serves as a raw material or intermediate in the synthesis of other silicone compounds, including silanes, siloxanes, and specialty silicone polymers.
Catalyst and Reagent:
In some reactions, it can function as a mild Lewis acid catalyst or as a source of chloride ions.
Why Choose Aure Chemical for Your Chlorotrimethylsilane Supply?
Aure Chemical is dedicated to providing superior chemical solutions and unparalleled customer support. By partnering with us for your Chlorotrimethylsilane requirements, you benefit from:
Exceptional Purity & Consistent Quality: Our Chlorotrimethylsilane is manufactured to stringent purity specifications, crucial for optimizing performance and selectivity in sensitive organic synthesis reactions, particularly in pharmaceutical and fine chemical production.
Uncompromising Safety & Compliance: Given the hazards associated with Chlorotrimethylsilane, Aure Chemical maintains world-class safety standards. Our manufacturing, storage, and transportation protocols are meticulously designed to adhere strictly to international safety regulations and best practices for handling highly reactive, flammable, and corrosive liquids.
Reliable Global Supply Chain: We maintain a robust and efficient global supply network, guaranteeing timely and secure delivery of this critical chemical to your facilities worldwide, with specialized logistics for hazardous liquids.
Expert Technical & Safety Support: Our dedicated team of experienced chemists and highly trained safety specialists is readily available to offer comprehensive guidance on product application, stringent safe handling procedures, emergency response planning, and optimal storage conditions for Chlorotrimethylsilane.
Commitment to Quality & Responsible Stewardship: We adhere to the highest industry standards for quality management, environmental responsibility, and product stewardship across all our operations, ensuring peace of mind for our clients and the responsible management of hazardous chemicals.
Choose Aure Chemical for a trustworthy and dependable supply of high-quality Chlorotrimethylsilane. We're ready to support your most demanding and innovative chemical processes with an unwavering commitment to safety and excellence.
Packaging, Transportation & Storage Solutions
At Aure Chemical, we understand the critical importance of rigorous packaging, transportation, and storage for chemical products. To ensure the safety and integrity of the products you purchase, and to comply with international and national regulations, we provide the following general guidelines. Please note that each specific product has its own Safety Data Sheet (SDS), which contains the most detailed and authoritative information on packaging, transportation, and storage. We strongly advise you to consult and strictly adhere to the SDS for the respective product.
Safety & Storage — Chlorotrimethylsilane (CAS 75-77-4)
Hazard Classification
GHS Classification: Flammable liquid (Category 3), Corrosive to skin and eyes (Category 1), Acute Toxicity (Category 4)
Hazard Statements: H226 (Flammable liquid and vapor), H314 (Causes severe skin burns and eye damage), H302 (Harmful if swallowed), H335 (May cause respiratory irritation)
Storage Conditions
Store in a cool, dry, and well-ventilated area.
Keep container tightly closed and sealed under inert gas (e.g., nitrogen or argon).
Protect from moisture and water — reacts violently with water, releasing HCl gas.
Segregate from oxidizers, alcohols, bases, and acids.
Packaging Recommendations
Commonly supplied in 25 L or 200 L steel drums with corrosion-resistant liners.
For laboratory scale: sealed amber glass bottles or metal containers with PTFE-lined caps.
Ensure packaging is moisture-tight and properly labeled as a corrosive and flammable chemical.
Transport Information
UN Number: UN 1992 (Flammable liquids, toxic, n.o.s., containing Chlorotrimethylsilane)
Hazard Class: 3 (Flammable liquids), with subsidiary risk of Corrosive (Class 8)
Packing Group: II
Transport according to ADR/RID, IMDG, IATA regulations. Avoid transport with incompatible cargos.
Spill Response, Disposal & First Aid
Spill Response
Immediate actions: Evacuate non-essential personnel and isolate the area. Eliminate all ignition sources (no smoking, no sparks, no flames).
Ventilation: Provide local exhaust or natural ventilation. If indoors, increase ventilation and, if necessary, use explosion-proof fans.
PPE for responders: Chemical resistant gloves (e.g., Viton® or butyl), chemical splash goggles/face shield, chemical-resistant apron/coveralls, and suitable respirator (e.g., full-face with appropriate cartridges or supplied-air) when exposure may exceed limits.
Do NOT use water: TMSCl reacts violently with water and moisture to release HCl — do not rinse with water or use aqueous neutralizers directly on the spill.
Containment & cleanup: Cover small spills with dry, inert absorbent (e.g., dry sand, dry vermiculite) and collect into dry, labeled, sealable containers. For large spills, form a dry containment barrier to prevent spread and contact emergency response contractor.
Prevent environmental release: Prevent material from entering drains, sewers or waterways. If contamination of drains or waterways occurs, notify appropriate authorities immediately.
Decontamination: After bulk material is removed, ventilate affected area and wipe down surfaces with an appropriate solvent recommended by SDS (only by trained personnel) — consult SDS before any decontamination step.
Disposal
Hazardous waste: Collected spill residues, contaminated absorbents, and unused TMSCl are hazardous waste and must be managed according to local and national regulations.
Do not pour down drains: Never dispose of TMSCl or its residues into sewer systems, drains, or open water.
Neutralization caution: Do not attempt on-site neutralization with water or strong bases unless performed by trained personnel with appropriate controls — hydrolysis produces corrosive HCl and heat.
Licensed contractor: Engage a licensed hazardous-waste contractor for collection, transport and disposal. Provide them with SDS and all relevant hazard/transport information.
Documentation: Keep records of waste volumes, containers, transport manifests and disposal certificates as required by regulation.
First Aid Measures
Inhalation: Move the exposed person to fresh air immediately. If breathing is difficult, administer oxygen if trained to do so and seek medical attention. If not breathing, begin CPR and call emergency services.
Skin contact: Remove contaminated clothing and shoes. Immediately brush off dry material (do not rinse with water). Then wash affected skin with plenty of water and soap for at least 15 minutes. Seek medical attention for burns or persistent irritation.
Eye contact: Rinse cautiously with water for at least 15 minutes. Remove contact lenses if present and easy to do. Seek immediate medical attention — inform medical staff that exposure may involve hydrogen chloride from hydrolysis.
Ingestion: Do NOT induce vomiting. Rinse mouth with water (only if the person is conscious and can swallow). Get immediate medical attention and show SDS if possible.
Notes for clinicians: Exposure may involve both parent compound and hydrolysis products (HCl). Treat symptomatically and supportively; monitor airway and respiratory function.
Emergency contacts: Provide local emergency telephone numbers and your company emergency contact / transport emergency card (EMERGENCY PHONE:+86 18653390106).
Important: The above first aid guidance is general. Always follow the product's SDS and consult medical professionals. If possible, have the SDS available for emergency responders.
GHS05: Corrosive pictogram
GHS07: Irritant / Harmful
GHS08: Health hazardImportant: Always consult the official Safety Data Sheet (SDS) for complete hazard classification, regulatory compliance, and handling instructions.
Packaging
Frequently Asked Questions (FAQ)
What is Chlorotrimethylsilane (TMSCl)?
Chlorotrimethylsilane (TMSCl, CAS 75-77-4) is an organosilicon compound with the formula (CH3)3SiCl.
It is a clear, volatile, flammable liquid used primarily as a reagent in organic synthesis and as a building block for organosilicon materials.
What are the main uses of Chlorotrimethylsilane?
TMSCl is widely used in chemical synthesis, especially for silylation reactions where it protects hydroxyl and amino groups.
It is also employed in the production of silicones, pharmaceutical intermediates, agrochemicals, and specialty polymers.
Is Chlorotrimethylsilane hazardous?
Yes. TMSCl is classified as flammable, corrosive, and harmful.
It reacts violently with water to release hydrogen chloride (HCl), which is highly irritating and corrosive to skin, eyes, and the respiratory tract.
Is Chlorotrimethylsilane flammable?
Yes. TMSCl is a flammable liquid (GHS02) with a low flash point.
It should be handled and stored away from ignition sources, heat, and sparks.
How should Chlorotrimethylsilane be stored?
Store in a tightly sealed container under an inert gas (nitrogen or argon).
Keep in a cool, dry, and well-ventilated place. Protect from moisture, acids, alcohols, and oxidizing agents.
What packaging options are available?
Chlorotrimethylsilane is typically supplied in 200 L steel drums and tanks with corrosion-resistant liners.
For laboratory use, it may be packaged in sealed glass bottles with PTFE-lined caps.
What is the UN number and transport classification?
The transport classification is UN 1298 (Flammable liquids, toxic, n.o.s., containing Chlorotrimethylsilane).
It falls under Hazard Class 3 (Flammable Liquids) with subsidiary risk Class 8 (Corrosive), Packing Group II.
Can Aure Chemical supply bulk quantities of Chlorotrimethylsilane?
Yes. Aure Chemical supplies Chlorotrimethylsilane in both laboratory scale and industrial bulk packaging.
Options include 25 L containers, 200 L drums, and custom packaging solutions for safe global delivery.
