Aure Chemical Delivers Excellence in Trihexylphosphine
Trihexylphosphine (THP) (CAS 4168-73-4) is a high-molecular-weight tertiary alkylphosphine valued in specialized synthetic and industrial applications. It is a colorless to pale yellow, slightly viscous liquid with the characteristic strong, pungent, garlic-like odor common to phosphines. THP possesses a unique combination of high electron richness (due to the alkyl groups) and enhanced lipophilicity (due to the long hexyl chains). This lipophilic character makes THP an excellent phase-transfer catalyst and a superb ligand for non-polar solvent systems, often preferred over shorter-chain phosphines like tributylphosphine due to its lower volatility and higher thermal stability.
Basic Information of THP
Meticulously produced and rigorously tested to meet stringent quality standards. We ensure exceptional purity and consistent performance, essential for your critical applications:
| CAS No.: | 4168-73-4 |
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| EC No.: | 224-025-3 |
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| Linear Formula: | C18H39P |
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| Molecular Weight: | 286.48 |
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| Appearance: | Colorless to pale yellow, slightly viscous liquid |
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| Odor: | Strong, highly pungent, garlic-like |
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| Melting Point: | 20℃ |
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| Boiling Point: | 227 °C / 50mmHg |
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| Density: | 0,83 g/cm3 |
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| Solubility: | Insoluble in water; highly soluble in organic solvents, oils, and non-polar media. |
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| RIDADR: | UN 3254 4.2 PG I |
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| Chemical Structure: |  |
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Application Overview
Trihexylphosphine's high lipophilicity and low volatility distinguish it, making it crucial for processes requiring specialized solubility or high temperatures:
Phase-Transfer Catalysis (PTC): The long alkyl chains enable THP to efficiently mediate reactions between aqueous and organic phases, acting as an effective phase-transfer catalyst or co-catalyst in two-phase systems, where it solubilizes metal complexes in non-polar media.
High-Temperature Catalysis: Due to its high boiling point and thermal stability, THP is the preferred phosphine ligand for demanding metal-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) that must be run at elevated temperatures where shorter-chain phosphines would boil off or degrade.
Nanomaterials Synthesis: It is frequently used as a capping ligand or solvent in the high-temperature synthesis of quantum dots and metal nanoparticles. The long alkyl chains facilitate control over particle size and surface passivation.
Pharmaceutical Intermediates: Employed in the synthesis of complex organic molecules where its strong reducing power (e.g., in Mitsunobu or Staudinger-type reactions) and excellent solvent compatibility are leveraged.
Why Choose Aure Chemical for Trihexylphosphine?
Aure Chemical offers THP (CAS 4168-73-4) with specialized quality assurance protocols centered on maximizing its thermal stability, purity, and safe handling for specialized industrial applications.
Enhanced Thermal Stability Certification: We provide thermal stability reports detailing the material's integrity over extended periods at elevated temperatures. This is vital for customers in catalysis and nanomaterials synthesis who operate high-temperature reaction protocols.
Guaranteed Low Phosphine Oxide (THPO): We strictly monitor and guarantee an oxidation product (THPO) content below 0.1%. This ensures the maximum available concentration of the active phosphine ligand, which is paramount for catalytic efficiency and minimizing reagent waste.
Customized Low-Volatility Packaging: Given its sensitivity to oxygen and its high boiling point, we ship THP in precision-cleaned, inert gas-blanketed containers with seals rated for high-temperature use. This preserves the reagent's purity and maximizes its shelf life in challenging industrial environments.
Traceability for Specialized Applications: We provide comprehensive documentation verifying the purity of the hexyl alkyl chain structure, minimizing isomer content. This high structural specificity ensures predictable ligand performance and binding characteristics required in sensitive materials science applications.
Hazards Classification
GHS Classification: Flammable Liquid (GHS02), Acute Toxicity Oral (GHS06), Skin Irritation (GHS07), Eye Irritation (GHS07)
Hazard Statements: Flammable liquid and vapor; Harmful if swallowed; Causes skin irritation; Causes serious eye irritation.
UN Number: UN 3254
Hazard Class: 4.2 (Pyrophoric liquids)
Packing Group: I
GHS02: Flammable
GHS06: Acute toxicity
GHS07: Irritant
