Discover Aure Chemical's Premium Trimethylsilyl Triflate (TMSOTf, CAS 27607-77-8) Supply
Aure Chemical is a premier global supplier of high-quality Trimethylsilyl Triflate, universally known by its abbreviation TMSOTf. Identified by its CAS number 27607-77-8, TMSOTf is a colorless to pale yellow liquid renowned as a highly potent and versatile Lewis acid and electrophilic silylating agent. Its exceptional reactivity, coupled with the strong leaving group ability of the triflate anion, makes it an indispensable tool in modern organic synthesis. TMSOTf is widely utilized to activate various functional groups, catalyze challenging reactions, and introduce trimethylsilyl groups, thereby facilitating the creation of complex molecular structures. Its applications span across pharmaceutical synthesis, agrochemical development, polymer chemistry, and advanced materials research. Aure Chemical is committed to providing TMSOTf that meets stringent purity and performance requirements, ensuring consistent and reliable results for your most demanding industrial and research applications. Partner with us for a dependable supply of this critical chemical.
Product Overview & Key Properties
Trimethylsilyl Triflate (TMSOTf, CAS No. 27607-77-8) is meticulously produced and rigorously tested to meet stringent quality standards. We offer various grades to suit your specific application requirements:
| CAS No.: | 27607-77-8 |
| EC No.: | 248-565-4 |
| Linear Formula: | CF₃SO₃Si(CH₃)₃ |
| Molecular Weight: | 222.26 |
| Appearance: | Colorless to pale yellow liquid. |
| Melting Point: | 25°C |
| Boiling point: | 77 °C/80 mmHg (lit.) |
| Density: | 1.228 g/mL at 25 °C (lit.) |
| Solubility: | Miscible with many organic solvents (e.g., dichloromethane, diethyl ether, toluene); hydrolyzes in water. |
| Stability: | Hydrolytically sensitive; must be stored under anhydrous conditions. |
| Purity: | Available in high purity grades (e.g., 99% min) for sensitive catalytic and synthetic applications. |
| Chemical Structure: |  |
Our commitment to delivering high-purity TMSOTf ensures a reliable and efficient component for your critical processes, offering consistent quality for diverse synthetic and industrial applications.
Primary Applications of Trimethylsilyl Triflate (TMSOTf)
Trimethylsilyl Triflate's unique combination of strong Lewis acidity and silylating ability makes it an invaluable reagent with significant applications in various advanced chemical processes:
Silylation Agent:
TMSOTf is an excellent reagent for introducing the trimethylsilyl (TMS) group into various molecules. This is particularly useful for:
Protecting Groups: Forms stable silyl ethers from alcohols, allowing for selective reactions at other sites.
Forming Enol Ethers/Silyl Enol Ethers: Reacts with ketones and aldehydes to form silyl enol ethers, which are versatile intermediates in aldol reactions, Michael additions, and other carbon-carbon bond forming reactions.
Lewis Acid Catalyst:
Its strong Lewis acidity makes TMSOTf a powerful catalyst for a wide range of organic transformations, including:
Glycosylation Reactions: Highly effective in promoting the formation of glycosidic bonds in carbohydrate chemistry, crucial for synthesizing complex oligosaccharides.
Aldol and Mukaiyama Aldol Reactions: Catalyzes the addition of enolates (or silyl enol ethers) to aldehydes and ketones.
Friedel-Crafts Reactions: Promotes alkylation and acylation reactions on aromatic compounds.
Rearrangements and Cyclization Reactions: Facilitates various complex molecular rearrangements and ring-forming reactions.
Activating Agent:
TMSOTf is used to activate various functional groups, transforming them into more reactive species. For example, it can activate alcohols and thiols for subsequent nucleophilic attack.
Pharmaceutical and Agrochemical Synthesis:
It is a critical reagent in the synthesis of complex active pharmaceutical ingredients (APIs) and agrochemicals, enabling challenging stereoselective reactions and the construction of intricate molecular architectures.
Polymer Chemistry:
TMSOTf can be employed as an initiator or catalyst in certain polymerization reactions, particularly those involving cationic polymerization, influencing polymer properties and molecular weight distribution.
Why Choose Aure Chemical for Your Trimethylsilyl Triflate (TMSOTf) Supply?
Aure Chemical is dedicated to providing superior chemical solutions and unparalleled customer support. By partnering with us for your TMSOTf requirements, you benefit from:
Exceptional Purity & Consistent Quality: Our Trimethylsilyl Triflate is manufactured to stringent purity specifications, crucial for achieving optimal and reproducible results in sensitive organic syntheses and demanding industrial processes.
Reliable Global Supply Chain: We maintain a robust and efficient global supply network, guaranteeing timely and secure delivery of this essential, moisture-sensitive chemical to your facilities worldwide, with specialized packaging and handling expertise.
Expert Technical Support: Our dedicated team of specialists is readily available to offer comprehensive guidance on product application, safe handling procedures, optimal storage, and usage in your specific chemical processes, ensuring maximum safety and efficiency.
Commitment to Quality & Responsible Stewardship: We adhere to the highest industry standards for quality management, environmental responsibility, and product stewardship across all our operations, ensuring peace of mind for our clients and sustainable sourcing practices.
Customized Solutions: We understand that different applications may require specific purity levels or formulations. We are open to discussing customized solutions to meet your exact requirements.
Choose Aure Chemical for a trustworthy and dependable supply of high-quality Trimethylsilyl Triflate (TMSOTf). We're ready to empower your most advanced chemical synthesis and research endeavors with an unwavering commitment to quality and excellence.
Packaging, Transportation & Storage Solutions
At Aure Chemical, we understand the critical importance of rigorous packaging, transportation, and storage for chemical products. To ensure the safety and integrity of the products you purchase, and to comply with international and national regulations, we provide the following general guidelines. Please note that each specific product has its own Safety Data Sheet (SDS), which contains the most detailed and authoritative information on packaging, transportation, and storage. We strongly advise you to consult and strictly adhere to the SDS for the respective product.
| I. Packaging Solutions | II. Transportation Solutions | III. Storage Solutions |
We utilize various UN (United Nations) certified packaging containers based on the chemical nature, hazard class, and transportation requirements of our products. Common packaging types include, but are not limited to: Steel Drums: Suitable for a wide range of liquid and solid products, especially flammable liquids. Plastic Drums/Jerricans: Primarily used for corrosive liquids like acids and bases, or substances incompatible with metal. Composite Drums: Combine the corrosion resistance of a plastic inner liner with the strength of a steel or fiber outer shell. IBCs (Intermediate Bulk Containers): Often referred to as "Tote Bins" or "Cubic Tanks," these are used for larger volumes of liquid or solid dangerous goods, offering efficient storage and transport solutions. Lined Bags or Fibre Drums: Primarily used for powdered or granular solids. Glass Bottles: Typically used as inner packaging for small quantities of high-purity or specialized chemicals, requiring additional absorbent material and sturdy outer packaging (e.g., wooden crates, fiberboard boxes). Steel Cylinders: Specifically designed and constructed as pressure vessels for the storage and transport of compressed, liquefied, or dissolved gases. Available in various capacities and pressure ratings, they are built to withstand high internal pressures and ensure the safe containment of gaseous substances.
All packaging undergoes stringent testing and complies with UN packaging performance levels to ensure product safety under normal transport conditions. | We strictly adhere to international and regional regulations for the transport of dangerous goods, ensuring full compliance and safety from our facility to your delivery point. Sea Freight (IMDG Code): We strictly comply with the International Maritime Dangerous Goods (IMDG) Code, using UN-certified containers and ensuring proper dangerous goods declaration, marking, and stowage. Air Freight (IATA DGR): We follow the International Air Transport Association (IATA) Dangerous Goods Regulations, which impose the strictest requirements for packaging, labeling, documentation, and quantity limitations. Road/Rail Transport (ADR/RID & Local Regulations): We comply with the European Agreement concerning the International Carriage of Dangerous Goods by Road (ADR), the Regulations concerning the International Carriage of Dangerous Goods by Rail (RID), and specific national/regional regulations to ensure safe land transport.
Regardless of the transport mode, we will provide the following essential documentation: Safety Data Sheet (SDS/MSDS): Provides product hazard information, safe handling guidelines, emergency measures, etc. Dangerous Goods Declaration (DGD): Detailed information on dangerous goods, packing group, UN number, etc., for carriers and relevant authorities. Other Necessary Certifications or Documents: Such as Certificates of Analysis (COA).
Upon receiving your shipment, please carefully verify the integrity of the packaging and the label information.
| Proper storage is crucial for maintaining product quality and ensuring operational safety. The following are general storage principles: Dedicated Areas: Dangerous chemicals should be stored in designated warehouses or areas that meet safety standards, away from residential zones and densely populated areas. Segregated Storage: Strictly classify and segregate products according to their hazard class to prevent incompatible substances from being stored together and causing dangerous reactions (e.g., acids and bases separated, flammables away from oxidizers). Good Ventilation: Storage areas should maintain good natural or forced ventilation to prevent the accumulation of hazardous gases or vapors. Temperature & Humidity Control: Control the temperature and humidity of the storage environment according to the recommendations in the SDS. Avoid direct sunlight and extreme temperatures. Fire and Explosion Prevention: Storage areas for flammable and explosive products should be equipped with adequate fire-fighting equipment, prohibit open flames, and ensure electrical equipment meets explosion-proof standards. Clear Labeling: All storage containers and areas should have clear, conspicuous hazard labels and warning signs. Spill Response: Storage areas should be equipped with appropriate spill response equipment and materials, and personnel should be familiar with emergency procedures. Regular Inspections: Periodically inspect the integrity of storage containers to ensure no leaks or damage, and verify label information. Away from Food and Drinking Water: Avoid cross-contamination.
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| Should you have any questions regarding the packaging, transportation, or storage of specific products, or require a customized solution, please do not hesitate to contact us. |
