Discover Aure Chemical's Premium Trifluoroacetic Acid (CAS 76-05-1) Supply
Aure Chemical is a leading global supplier of Trifluoroacetic Acid (TFA), also known as 2,2,2-Trifluoroethanoic acid. This highly versatile and exceptionally strong organic acid is a cornerstone in advanced chemistry, prized for its unique combination of strong acidity, excellent solvent properties, and high volatility. TFA is an indispensable reagent, catalyst, and solvent across a broad spectrum of high-tech industries and research applications.
Product Overview & Key Properties
Trifluoroacetic Acid (CAS No. 76-05-1) is manufactured to the highest purity standards, ensuring optimal performance and reliability for your most demanding applications:
| CAS No.: | 76-05-1 |
| EC No.: | 200-929-3 |
| Linear Formula: | CF₃COOH |
| Molecular Weight: | 114.02 |
| Appearance: | Transparent Liquid |
| Odor: | Pungent, sharp, vinegar-like odor |
| Melting Point: | -15.2 °C |
| Boiling point | 72 °C |
| Density: | 1.489 g/mL at 25 °C |
| Solubility: | Miscible with water and most organic solvents. |
| Nature: | Extremely corrosive, highly volatile, strong acid (stronger than sulfuric acid), non-oxidizing. |
| RIDADR: | UN 2699 8/PG 1 |
| Chemical Structure: |  |
Our commitment to delivering high-purity TFA ensures consistent and superior results for your specialized synthesis and analytical needs.
Primary Applications of Trifluoroacetic Acid (TFA)
Trifluoroacetic Acid's unique chemical profile, characterized by its strong acidity and the electron-withdrawing effects of its fluorine atoms, drives its extensive utility:
Peptide Synthesis & Protein Chemistry:
TFA is absolutely critical in solid-phase peptide synthesis (SPPS), where it's used to deprotect N-terminal Boc (tert-butyloxycarbonyl) groups. Its high volatility allows for easy removal after reaction, making it ideal for the sequential synthesis of peptides and proteins.
Pharmaceutical & Agrochemical Manufacturing:
As a powerful catalyst and solvent, TFA plays a vital role in the synthesis of various active pharmaceutical ingredients (APIs) and agrochemicals. It's used in numerous reactions requiring strong acidic conditions, such as esterifications, alkylations, and acylations.
Chromatography & Analytical Chemistry:
TFA is a common mobile phase modifier in High-Performance Liquid Chromatography (HPLC), particularly for separating peptides, proteins, and other polar compounds. Its volatility ensures it won't interfere with subsequent mass spectrometry analysis, making it an ideal ion-pairing reagent.
Polymer Science & Advanced Materials:
Used as a solvent for dissolving various polymers (e.g., polyamides, polyesters) that are otherwise insoluble in common organic solvents. It also serves as a reagent in the synthesis of specialized fluoropolymers and other advanced materials.
General Organic Synthesis:
Beyond its specific applications, TFA acts as a versatile strong acid catalyst, solvent, and reagent for numerous organic reactions, including Friedel-Crafts acylations, deprotections, and oxidation reactions.
Why Choose Aure Chemical for Your Trifluoroacetic Acid (TFA) Supply?
Aure Chemical is dedicated to providing superior chemical solutions and unparalleled customer support. By partnering with us for your Trifluoroacetic Acid requirements, you benefit from:
Exceptional Purity: Our TFA is manufactured to the highest purity specifications, crucial for sensitive applications like peptide synthesis and analytical chromatography.
Reliable Global Supply: We maintain a robust and efficient supply chain, guaranteeing timely and secure delivery of this specialized chemical to your facilities worldwide.
Expert Technical Support: Our team of experienced chemists and specialists is readily available to offer comprehensive guidance on product application, safe handling, and storage of TFA.
Commitment to Quality & Safety: We adhere to the highest industry standards for quality management, safety, and environmental responsibility across all our operations.
Choose Aure Chemical for a trustworthy and dependable supply of high-quality Trifluoroacetic Acid. We are ready to support your most complex and innovative chemical endeavors.
Frequently Asked Questions (FAQ)
What is Trifluoroacetic Acid (CAS 76-05-1)?
Trifluoroacetic Acid (TFA) is a strong, highly volatile organic acid with the formula C2HF3O2. It is widely used in organic synthesis as a reagent, catalyst, and solvent.
What are the main applications of Trifluoroacetic Acid?
TFA is commonly used in peptide synthesis, as a strong acid catalyst, in pharmaceutical intermediates, agrochemicals, and as a mobile phase additive in HPLC analysis.
What are the key physical properties of TFA?
TFA is a colorless liquid with a boiling point of 72.4 °C, density of 1.489 g/cm³, and a very low pKa (~0.23), making it a stronger acid than acetic acid.
Is Trifluoroacetic Acid hazardous?
Yes. TFA is classified as corrosive (GHS05) and harmful (GHS07). It causes severe skin burns and eye damage, and requires careful handling.
What precautions are required when handling TFA?
Use protective gloves, goggles, and chemical-resistant clothing. Handle in a fume hood to avoid inhalation of vapors, and keep away from incompatible substances such as bases and metals.
How should TFA be stored safely?
Store in tightly sealed containers, in a cool, dry, and well-ventilated area at 2–8 °C. Use PTFE-lined or glass containers to avoid corrosion of metal.
What packaging options are available for TFA?
TFA is available in sealed glass bottles (100 mL–1 L) for laboratory use, HDPE containers (5–25 kg), and UN-approved fluoropolymer-lined steel drums (200 L) for bulk shipments.
Can you supply bulk packaging (e.g., 200 L drums)?
Yes. We supply industrial-grade UN-approved 200 L lined steel drums suitable for international transport of corrosive substances.
Do you provide COA, MSDS, and other documents?
Yes. A Certificate of Analysis (COA), Safety Data Sheet (MSDS), and transport documents are provided with each batch shipment.
Is AureChem the manufacturer or supplier of TFA?
AureChem is a trusted global supplier of high-purity Trifluoroacetic Acid, offering consistent quality, reliable sourcing, and professional technical support.
Safety & Storage
Hazard Classification
GHS Classification: Corrosive to metals (Category 1), Acute Toxicity (Category 4, oral), Skin Corrosion (Category 1A), Serious Eye Damage (Category 1)
UN Number: UN 2699 (Trifluoroacetic acid)
Hazard Class: 8 (Corrosive substances)
Packing Group: II
Hazard Statements:
H290 (May be corrosive to metals),
H302 (Harmful if swallowed),
H314 (Causes severe skin burns and eye damage),
H318 (Causes serious eye damage)
Precautionary Statements:
P260 (Do not breathe vapors),
P280 (Wear protective gloves/eye protection),
P301+P330+P331 (IF SWALLOWED: Rinse mouth. Do NOT induce vomiting)
Storage Conditions
Store in tightly closed containers made of compatible materials (e.g., PTFE-lined or glass).
Keep in a cool, dry, and well-ventilated place.
Recommended storage temperature: 2–8 °C.
Separate from bases, oxidizing agents, and metals.
Transport Information
GHS05: Corrosive pictogram
GHS07: Harmful pictogram
Packaging
Related Articles
